Nitrogen for Liquid Chromatography Mass Spectrometry

What is LC-MS?

LC-MS is a separation technique for the analysis of compounds in a mixture, e.g. pharmaceutical products, which can identify and quantify compounds such as contaminant, degradation products or unknown compounds (e.g. in forensic science) in complex matrices. This separation technique is used in a wide range of industries (pharmaceutical development and manufacture, clinical biochemistry and toxicology, water purity testing and academic research).

How does it work?

A chemical mixture is first separated using liquid chromatography. The separated components are quantified or identified using a mass selective detector which allows accurate and reproducible measurement of amount of each component (”analyte”) present.

The benefits of the LC-MS in Analytical Chemistry

  1. The process can be used to identify and quantify complex compound mixes in challenging sample matrices, with relative speed and simplicity.
  2. Very sensitive technique, capable of measuring levels down to 0.000 000 000 000 000 001 (10-18) grams of compound.
  3. The technique allows faster analysis times to test substances, increased throughput and reducing labour costs for the laboratory.

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